N-[(6-Methoxypyridin-2-yl)methyl]acetamide → (6-Methoxypyridin-2-yl)methanamine
Reaction equation
C([NH:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[N:7]=1)(=O)C.Cl.NCC1C=CC=C(OC)N=1.Cl.NCC1NC(=O)C=CC=1>Cl>[NH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[N:7]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
The crude product, 2-acetamidomethyl-6-methoxypyridine from Part A, was combined with 10 ml of 6N hydrochloric acid, and the resulting mixture was heated at its reflux temperature for about 16 hours. The mixture was evaporated to provide a tan solid residue. The product was determined by infrared and nuclear magnetic resonance spectral analyses to be a mixture of 2-aminomethyl-6-methoxypyridine hydrochloride and 6-aminomethyl-2(1H)-pyridone hydrochloride.
Workup
- temperaturethe resulting mixture was heated at its
- temperaturereflux temperature for about 16 hours
- customThe mixture was evaporated
- customto provide a tan solid residue
Sources & evidence
- ORD record
- ord-f5b161a1df44478c97059ee14f21eb70
- Source dataset
- uspto-grants-1985_01
- Patent number
- US04496734
Reaction notes
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