Ammonium Hydroxide → 4-(Aminomethyl)oxan-4-ol

HRID 241651Notes

Reaction equation

HRID 241651 reaction equation
[O:1]1[C:3]2([CH2:8][CH2:7][O:6][CH2:5][CH2:4]2)[CH2:2]1.[NH4+:9].[OH-]>CO>[NH2:9][CH2:2][C:3]1([OH:1])[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 1604391,6-Dioxaspiro[2.5]octane

Product 1

HCID 436087544-(Aminomethyl)oxan-4-ol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The methanol solution of 1,6-dioxaspiro[2.5]octane (3.15 g, 27.6 mmol) was added to the 25% ammonia aqueous solution (50.0 mL, 27.6 mmol) at 0° C. The mixture was warmed to room temperature and stirred for 18 h. The reaction mixture was concentrated in vacuo. The crude product was used for next step reaction without purification.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe crude product was used for next step reaction without purification

Sources & evidence

ORD record
ord-fc00036b66ec41eeb5e44cf2df03e5b5
Source dataset
uspto-grants-2014_02
Patent number
US08653063B2

Reaction notes

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