Methanol → Methyl 4-chloroacetoacetate

HRID 2418482Notes

Reaction equation

HRID 2418482 reaction equation
Cl[C:2]1([CH2:7][Cl:8])[O:5][C:4](=[O:6])[CH2:3]1.[CH3:9][OH:10]>C(=O)(O)[O-].[Na+]>[CH3:9][O:10][C:4](=[O:6])[CH2:3][C:2]([CH2:7][Cl:8])=[O:5]

Participants

4

Reactant 2

HCID 887MethanolHCID 137182814-Chloro-4-(chloromethyl)oxetan-2-one

Product 1

HCID 36240Methyl 4-chloroacetoacetate

Reagents, catalysts & solvents 1

HCID 516892Sodium BicarbonateSolvent

Procedure

7.8 Parts of 4-chloro-4-chloromethyloxetan-2-one are dissolved in 200 parts of methanol containing 4.2 parts of anhydrous sodium bicarbonate. After stirring for 20 hours at room temperature, the solids are filtered off, the filtrate is evaporated and the residue distilled to give methyl-γ-chloroacetoacetate, b.p. 48°-50° C./0.8 mb.

Workup

  1. filtrationthe solids are filtered off
  2. customthe filtrate is evaporated
  3. distillationthe residue distilled

Sources & evidence

ORD record
ord-f4d83ff76a0c47e19a5a0dcaca20dabd
Source dataset
uspto-grants-1984_09
Patent number
US04472589

Reaction notes

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