Hydrochloric Acid → H-Gly-Leu-Met-Nh2 HCl
Reaction equation
[NH:1](C(OC(C)(C)C)=O)[CH2:2][C:3]([NH:5][C@H:6]([C:11]([NH:13][C@H:14]([C:19]([NH2:21])=[O:20])[CH2:15][CH2:16][S:17][CH3:18])=[O:12])[CH2:7][CH:8]([CH3:10])[CH3:9])=[O:4].[ClH:29]>C(O)(=O)C>[NH2:1][CH2:2][C:3]([NH:5][C@H:6]([C:11]([NH:13][C@H:14]([C:19]([NH2:21])=[O:20])[CH2:15][CH2:16][S:17][CH3:18])=[O:12])[CH2:7][CH:8]([CH3:10])[CH3:9])=[O:4].[ClH:29]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Condensation of BocGlyOH (4.4 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 7.5 g.) using dicyclohexylcarbodiimide and N-hydroxysuccinimide gave BocGly-Leu-MetNH2 in 51% yield. De-t-butoxycarbonylation of BocGly-Leu-MetNH2 using hydrogen chloride in acetic acid gave HGly-Leu-MetNH2 hydrochloride salt in 56% yield.