Ammonia → 6-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione

HRID 2418677

Reaction equation

HRID 2418677 reaction equation
Cl[CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1.[NH3:11]>C(OCC)(=O)C>[NH2:11][CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 732736-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 3129536-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 100 g (0.623 mole) of 6-chloromethylpyrimidine-2,4-dione and 200 ml of anhydrous ammonia was allowed to react overnight in a sealed bomb at about 20° C. The solid residue was slurried in ethyl acetate, separated by filtration, and washed sequentially with water and methanol to provide 6-aminomethylpyrimidine-2,4-dione, m.p. 295°-297° C.

Workup

  1. customto react overnight in a sealed bomb at about 20° C
  2. customseparated by filtration
  3. washwashed sequentially with water and methanol

Sources & evidence

ORD record
ord-579362fbdc4e4dc2bed4bbb1e3dcd3be
Source dataset
uspto-grants-1984_09
Patent number
US04473570

Linked notes

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