Cyclohexanecarboxylic acid → 1-Cyclohexyl-5-(1,4-diazepan-1-ylsulfonyl)isoquinoline

HRID 2418849Notes

Reaction equation

HRID 2418849 reaction equation
Cl.O=C(O)C1CCCCC1.O=S(=O)(c1cccc2cnccc12)N1CCCNCC1>CS(C)=O.N.O.O=S(=O)(O)OOS(=O)(=O)O>O=S(=O)(c1cccc2c(C3CCCCC3)nccc12)N1CCCNCC1

Participants

6

Reactant 2

HCID 7413Cyclohexanecarboxylic acidHCID 163751Fasudil Hydrochloride

Product 1

HCID 1782512711-Cyclohexyl-5-(1,4-diazepan-1-ylsulfonyl)isoquinolineYield 44%

Reagents, catalysts & solvents 3

HCID 21864320CID 21864320ReagentHCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Conditions

Temperature
40 °C

Sources & evidence

ORD record
ord-96470e19347144c3a3f2eb02aafad67c
Source dataset
Minisci dataset from Roche

Reaction notes

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