2-Cyanopyrimidine → Ethyl 3-(trifluoromethyl)isonicotinate

HRID 2418904Notes

Reaction equation

HRID 2418904 reaction equation
N#Cc1ncccn1.O=S(O)C(F)(F)F.[Zn]>CC(C)(C)OO.FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.O>CCOC(=O)c1ccncc1C(F)(F)F.N#Cc1nccc(C(F)(F)F)n1

Participants

7

Reactant 2

HCID 27579792-CyanopyrimidineHCID 89601280CID 89601280

Product 2

HCID 46311441Ethyl 3-(trifluoromethyl)isonicotinateYield 28%HCID 58358613HCID 58358613, compoundYield 11%

Reagents, catalysts & solvents 3

HCID 6410tert-Butyl hydroperoxideReagentHCID 962WaterSolventHCID 9639PerfluorohexaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-a4e46c9862f44f95a23ea67c1fddf2cf
Source dataset
Minisci dataset from Roche

Reaction notes

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