Ethyl 1-(methylsulfonyl)piperidine-4-carboxylate → (1-(Methylsulfonyl)piperidin-4-yl)methanol
Reaction equation
[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][CH:8]([C:11](OCC)=[O:12])[CH2:7][CH2:6]1)(=[O:4])=[O:3].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][CH:8]([CH2:11][OH:12])[CH2:7][CH2:6]1)(=[O:4])=[O:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Ethyl 1-(methylsulfonyl)piperidine-4-carboxylate 18 was reacted with lithium aluminum hydride in THF to give 19.
Sources & evidence
- ORD record
- ord-b5bc7ddce0724dbd8ab61f15955d17b8
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08653098B2
Reaction notes
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