Ethyl 6-oxo-2-(pentafluoroethyl)-1,6-dihydropyridine-3-carboxylate → 6-Oxo-2-(pentafluoroethyl)-1,6-dihydropyridine-3-carboxylic acid

HRID 2421031Notes

Reaction equation

HRID 2421031 reaction equation
[O:1]=[C:2]1[NH:7][C:6]([C:8]([F:14])([F:13])[C:9]([F:12])([F:11])[F:10])=[C:5]([C:15]([O:17]CC)=[O:16])[CH:4]=[CH:3]1>Cl>[O:1]=[C:2]1[NH:7][C:6]([C:8]([F:14])([F:13])[C:9]([F:10])([F:11])[F:12])=[C:5]([C:15]([OH:17])=[O:16])[CH:4]=[CH:3]1

Participants

3

Reactant 1

HCID 86611249Ethyl 6-oxo-2-(pentafluoroethyl)-1,6-dihydropyridine-3-carboxylate

Product 1

HCID 866112506-Oxo-2-(pentafluoroethyl)-1,6-dihydropyridine-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A suspension of ethyl 6-oxo-2-(pentafluoroethyl)-1,6-dihydropyridine-3-carboxylate (0.300 g) in concentrated hydrochloric acid (10 mL) was heated at reflux for 20 h. The reaction mixture was cooled and a colourless solid filtered off (0.30 g).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 20 h
  3. temperatureThe reaction mixture was cooled
  4. filtrationa colourless solid filtered off (0.30 g)

Sources & evidence

ORD record
ord-67aaf16c9a79433c8534522e96f7b38d
Source dataset
uspto-grants-2011_06
Patent number
US07956070B2

Reaction notes

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