Methylamine → 3-[(2-chloro-4-iodophenyl)amino]-N-methylisonicotinamide

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[CH3:19][NH2:20]>>[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:20][CH3:19])=[O:14]

Participants

Reactant 2

HCID 6329Methylamine

HCID 576496513-[(2-Chloro-4-iodophenyl)amino]isonicotinic acid2×

Product 1

HCID 116681963-[(2-chloro-4-iodophenyl)amino]-N-methylisonicotinamide

Procedure

3-[(2-chloro-4-iodophenyl)amino]-N-methylisonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.32 mmol of 3-[(2-chloro-4-iodophenyl)amino]isonicotinic acid (intermediate 2) and 0.43 mmol of monomethylamine LC/MS [9.23 min; 389 (M+1)]

Sources & evidence

ORD record: ord-4042f88beb1b4a21b78b15ce3a3b47b2
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07956191B2

Reaction notes

Loading…