Butyl bromide → 3-[4-[[3-[Butyl(phenyl)amino]benzyl]oxy]phenyl]propanoic acid
Reaction equation
[NH:1]([C:8]1[CH:9]=[C:10]([CH:25]=[CH:26][CH:27]=1)[CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][C:21]([O:23]C)=[O:22])=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:28](Br)[CH2:29][CH2:30][CH3:31]>>[CH2:28]([N:1]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:8]1[CH:9]=[C:10]([CH:25]=[CH:26][CH:27]=1)[CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][CH:18]=1)[CH2:29][CH2:30][CH3:31]Participants
3
Procedure
The title compound was synthesized in the same manner as in Example 302 from methyl 3-[4-[(3-anilinobenzyl)oxy]phenyl]propanoate and n-butylbromide. colorless crystals (yield 57%). MS (APCI−): 402 (M−H).
Sources & evidence
- ORD record
- ord-a8ac4d316c4c4d329967f0601cb530ed
- Source dataset
- uspto-grants-2011_06
- Patent number
- US07960369B2
Reaction notes
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