4-Pyrrolidinopyridine → 4-Hydrazino-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrimidine

HRID 242251

Reaction equation

HRID 242251 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][NH2:9])[N:5]=[CH:4][N:3]=1.[N:10]1([C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1>O>[NH:8]([C:6]1[CH:7]=[C:2]([N:18]2[CH2:19][CH2:20][CH:15]([N:10]3[CH2:14][CH2:13][CH2:12][CH2:11]3)[CH2:16][CH2:17]2)[N:3]=[CH:4][N:5]=1)[NH2:9]

Participants

4

Reactant 2

HCID 755674-PyrrolidinopyridineHCID 2472224-Chloro-6-hydrazinylpyrimidine

Product 1

HCID 596037004-Hydrazino-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrimidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2.0 g (13.8 mmol) of the compound from Example 7A and 4.3 g (27.7 mmol) 4-pyrrolidin-1-ylpyridine is stirred in 20 ml water at 100° C. for 16 h. The solid which has precipitated out is filtered off, washed first with ethanol and then with diethyl ether and dried in vacuo.

Workup

  1. customThe solid which has precipitated out
  2. filtrationis filtered off
  3. washwashed first with ethanol
  4. dry with materialwith diethyl ether and dried in vacuo

Sources & evidence

ORD record
ord-81a3b6e71fb7494a828fa00ee11f2cff
Source dataset
uspto-grants-2014_02
Patent number
US08653111B2

Linked notes

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