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Resorcinol → 4,4'-Dimethoxy-2-hydroxybenzophenone

HRID 2424187
Notes
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Reaction equation

HRID 2424187 reaction equation
[C:1]1(C=CC=C(O)C=1)O.COC1C=CC(C(Cl)=O)=CC=1.[OH:20][C:21]1[CH:26]=[C:25]([OH:27])[CH:24]=[CH:23][C:22]=1[C:28]([C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1)=[O:29].CI>>[OH:20][C:21]1[CH:26]=[C:25]([O:27][CH3:1])[CH:24]=[CH:23][C:22]=1[C:28]([C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1)=[O:29]
ParticipantsProcedureSources & evidenceReaction notes

Participants

5

Reactant 4

HCID 5054ResorcinolHCID 6328Methyl iodideHCID 7477p-Anisoyl chlorideHCID 350227(2,4-Dihydroxyphenyl)(4-methoxyphenyl)methanone

Product 1

HCID 961544,4'-Dimethoxy-2-hydroxybenzophenone

Procedure

Synthesized from resorcinol and 4-methoxybenzoyl chloride according to an analogous synthetic method to Preparation Example 66, (2,4-dihydroxyphenyl)(4-methoxyphenyl)methanone (9.7 g) and methyl iodide (13.1 g) were used according to an analogous synthetic method to Example 383 to provide the title compound (7.0 g).

Sources & evidence

ORD record
ord-4cb8ab3a6b8649b298359e4589277b9d
Source dataset
uspto-grants-2011_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07960412B2

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes