5-Fluoroisatin → 5-fluoro-1,3-dihydro-2H-indol-2-one
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O>O.NN>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
5-Fluoroisatin (8.2 g) was dissolved in 50 mL of hydrazine hydrate and refluxed for 1.0 hr. The reaction mixtures were then poured in ice water. The precipitate was then filtered, washed with water and dried in a vacuum oven to afford the title compound.
Workup
- temperaturerefluxed for 1.0 hr
- customThe reaction mixtures
- filtrationThe precipitate was then filtered
- washwashed with water
- customdried in a vacuum oven
Sources & evidence
- ORD record
- ord-85f8d0a13c1741908216e141c66ffd9d
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06855730B2
Reaction notes
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