HCID 58356410, compound → HCID 58356391, compound
Reaction equation
C([O:3][CH:4](OCC)[C:5]1[S:6][C:7]([CH:15]([CH3:17])[CH3:16])=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:9]=1)C>Cl.CC(C)=O>[CH:4]([C:5]1[S:6][C:7]([CH:15]([CH3:16])[CH3:17])=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:9]=1)=[O:3]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of ethyl 2-[bis(ethyloxy)methyl]-5-(1-methylethyl)-1,3-thiazole-4-carboxylate (430 mg) in a mixture of 10% 1M hydrochloric acid solution in acetone (50 ml) was heated at reflux for 1 h. The mixture was concentrated in vacuo, taken up in DCM (20 ml), washed with saturated sodium bicarbonate solution (10 ml), separated by hydrophobic frit and evaporated to give the title compound as a yellow oil (324 mg).
Workup
- temperaturewas heated
- temperatureat reflux for 1 h
- concentrationThe mixture was concentrated in vacuo
- washwashed with saturated sodium bicarbonate solution (10 ml)
- customseparated by hydrophobic frit
- customevaporated
Sources & evidence
- ORD record
- ord-9f69d89128984d8d9d098b578146c644
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08658635B2
Reaction notes
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