Benzylamine → 1-[(Phenylmethyl)amino]-2-butanol
Reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:9]1[CH:11]([CH2:12][CH3:13])[CH2:10]1>C(O)C>[CH2:1]([NH:8][CH2:10][CH:11]([OH:9])[CH2:12][CH3:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 150 °C
Procedure
To a solution of benzylamine (29.65 g, 277.0 mmol) in ethanol (40 mL) was added 1,2-epoxybutane (4 g, 55.47 mmol) and the mixture was heated to 150° C. for 2 h in a autoclave. It was concentrated and distilled at 140-150° C./2 mm Hg to give product as color less liquid, which slowly crystallizes at room temperature after 2 days. Yield: 8.5 g (85%)
Workup
- concentrationIt was concentrated
- distillationdistilled at 140-150° C./2 mm Hg
- customto give product as color less liquid, which
- customslowly crystallizes at room temperature after 2 days
Sources & evidence
- ORD record
- ord-52431dc6821d4426b2ef62ca31e803e2
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08658641B2
Reaction notes
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