Glycine ethyl ester → Ethyl 2-(2-hydroxy-3-methoxypropylamino)acetate

HRID 25038

Reaction equation

HRID 25038 reaction equation
[CH3:1][O:2][CH2:3][CH:4]1[O:6][CH2:5]1.[CH2:7]([O:9][C:10](=[O:13])[CH2:11][NH2:12])[CH3:8]>C(O)C>[OH:6][CH:4]([CH2:3][O:2][CH3:1])[CH2:5][NH:12][CH2:11][C:10]([O:9][CH2:7][CH3:8])=[O:13]

Participants

4

Reactant 2

HCID 12176Glycine ethyl esterHCID 135891,2-Epoxy-3-methoxypropane

Product 1

HCID 21922545Ethyl 2-(2-hydroxy-3-methoxypropylamino)acetateYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of glycidyl methyl ether (1.00 g) and glycine ethyl ester (5.91 g) in ethanol was stirred overnight, and concentrated under reduced pressure to obtain the title compound (2.17 g).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-375d93cfbe1742b5bc1217472b0ae0b6
Source dataset
uspto-grants-2005_02
Patent number
US06858599B2

Linked notes

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