1,2-Dichloroethane → Tropolone

HRID 251791

Reaction equation

HRID 251791 reaction equation
S(C1CC(=O)N(O)C1=O)(O)(=O)=O.C(Cl)CCl.[CH:17]1[C:24](N)=[CH:23][CH:22]=[C:21]([OH:26])[C:19](=[O:20])[CH:18]=1>C(=O)([O-])[O-].CS(C)=O>[CH:24]1[CH:17]=[CH:18][C:19](=[O:20])[C:21]([OH:26])=[CH:22][CH:23]=1

Participants

6

Reactant 3

HCID 111,2-DichloroethaneHCID 234505-Amino-2-hydroxy-2,4,6-cycloheptatrien-1-oneHCID 133909N-Hydroxysulfosuccinimide

Product 1

HCID 10789Tropolone

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 19660Carbonate IonSolvent

Procedure

To 100E6 carboxylated microspheres (previously activated with sulfo-N-hydroxysuccinimide and EDC) in 0.5 mL of carbonate buffer (pH 9) was added 2 mg of 5-aminotropolone dissolved in 25 μL of dimethyl sulfoxide. The suspension was agitated for 4 hours, and the excess reagent was washed away from the microspheres.

Workup

  1. washthe excess reagent was washed away from the microspheres

Sources & evidence

ORD record
ord-a3f5b91bacba4e389953cdb821e81d21
Source dataset
uspto-grants-2011_01
Patent number
US07867774B2

Linked notes

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