Hydrochloric Acid → 3-(Imidazo[1,2-b]pyridazin-2-yl)benzoic acid

HRID 251824Notes

Reaction equation

HRID 251824 reaction equation
[N:1]1[C:2]([C:10]2[CH:11]=C([CH:15]=[CH:16][CH:17]=2)C#N)=[CH:3][N:4]2[C:9]=1[CH:8]=[CH:7][CH:6]=[N:5]2.[OH-:18].[Na+].Cl.[CH3:21][CH2:22][OH:23]>O>[N:1]1[C:2]([C:10]2[CH:11]=[C:21]([CH:15]=[CH:16][CH:17]=2)[C:22]([OH:18])=[O:23])=[CH:3][N:4]2[C:9]=1[CH:8]=[CH:7][CH:6]=[N:5]2

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 534394773-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile

Product 1

HCID 576868123-(Imidazo[1,2-b]pyridazin-2-yl)benzoic acidYield 60%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 3-(imidazo[1,2-b]pyridazin-2-yl)benzonitrile (1 mmol) and 6M NaOH (2 ml) in EtOH was heated to reflux for 2 h. Then the mixture was diluted with water and acidified with HCl. The precipitate was filtered to give 3-(imidazo[1,2-b]pyridazin-2-yl)benzoic acid with a yield of 60%.

Workup

  1. temperatureto reflux for 2 h
  2. filtrationThe precipitate was filtered

Sources & evidence

ORD record
ord-2ba402ee2f5b4b6088104a6e4937924a
Source dataset
uspto-grants-2011_01
Patent number
US07868001B2

Reaction notes

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