Hydrochloric Acid → HCID 66887928, compound

HRID 252379

Reaction equation

HRID 252379 reaction equation
[CH3:1][O:2][C:3](=[O:13])[C:4]([CH3:12])([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)[CH3:5].[ClH:14]>CO.O.[Pt](=O)=O>[ClH:14].[CH3:1][O:2][C:3](=[O:13])[C:4]([CH3:5])([CH:6]1[CH2:11][CH2:10][CH2:9][NH:8][CH2:7]1)[CH3:12]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 54537815HCID 54537815, compound

Product 1

HCID 66887928HCID 66887928, compound

Reagents, catalysts & solvents 2

HCID 11139377Platinum dioxide monohydrateCatalystHCID 887MethanolSolvent2×

Procedure

A mixture of 0.823 g of 2-methyl-2-pyridin-3-yl-propionic acid methyl ester [476429-23-9] and 0.062 g of platinum(IV) oxide hydrate in 8 ml of methanol and 1.7 ml of 1.2M HCl in methanol at room temperature is hydrogenated for 5.5 hours. The catalyst is removed by filtration over Hyflo and the filtrate is concentrated by evaporation to provide the crude title compound as a brown oil which is used in the next step without further purification.

Workup

  1. customThe catalyst is removed by filtration over Hyflo
  2. concentrationthe filtrate is concentrated by evaporation

Sources & evidence

ORD record
ord-6d202131da254efb96a29d25c4b84ec3
Source dataset
uspto-grants-2011_01
Patent number
US07868036B2

Linked notes

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