3-Methoxybenzaldehyde → 4-Iodomethyl-2-(3-methoxyphenyl)-5-phenyloxazole

Reaction equation

[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17](C)=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C1([C:27](=[O:32])C(=NO)C)C=CC=CC=1.C(=O)C1C=CC=C(OC)C=1>>[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:32][CH3:27])[CH:15]=2)[O:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

Reactant 3

HCID 115693-Methoxybenzaldehyde

HCID 63990241,2-Propanedione, 1-phenyl-, 2-oxime

HCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 574345054-Iodomethyl-2-(3-methoxyphenyl)-5-phenyloxazole

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, 1-phenyl-1,2-propanedione-2-oxime and m-anisaldehyde gave 4-iodomethyl-2-(3-methoxyphenyl)-5-phenyloxazole.

Sources & evidence

ORD record: ord-af8bf56934244487be13ba3055663c04
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07872034B2

Reaction notes

Loading…