Benzaldehyde → 4-(Chloromethyl)-5-methyl-2-phenyl-1,3-oxazole

Reaction equation

[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17](C)=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1C=CC=CC=1.C/C(/C(C)=O)=N\O.C(=O)C1C=CC=CC=1>>[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[O:6][C:7]=1[CH3:8]

Participants

Reactant 3

HCID 240Benzaldehyde

HCID 64096332,3-Butanedione monoxime

HCID 574345034-Chloromethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 97942894-(Chloromethyl)-5-methyl-2-phenyl-1,3-oxazole

Procedure

Analogously to the building block synthesis of 4-chloromethyl-5-phenyl-2-p-tolyloxazole, diacetylmonoxime and benzaldehyde gave 4-chloromethyl-5-methyl-2-phenyloxazole.

Sources & evidence

ORD record: ord-ce8cb928e7a54bd98682e12ac4515e0d
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07872034B2

Reaction notes

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