Methylamine → N-methyl-5-nitropyridin-2-amine
Reaction equation
[CH3:1][NH2:2].Cl[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][N:5]=1>ClCCl>[CH3:1][NH:2][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][N:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Methylamine gas was bubbled through a stirred solution of 2-chloro-5-nitropyridine (4 g, 25.2 mmol) in dichloromethane (60 mL), at room temperature, until saturation had occurred. The resulting yellow precipitate was then filtered off, washed with dichloromethane and dried under vacuum to afford the title compound as a yellow solid in 80% yield, 3.07 g.
Workup
- filtrationThe resulting yellow precipitate was then filtered off
- washwashed with dichloromethane
- customdried under vacuum
Sources & evidence
- ORD record
- ord-54ea1faa8e804387b6c55cbb2b3de74e
- Source dataset
- uspto-grants-2011_01
- Patent number
- US07875615B2
Reaction notes
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