Acetic Anhydride → N-(4-Fluoro-2-(4-methyl-1H-imidazol-1-yl)phenyl)acetamide

HRID 254292

Reaction equation

HRID 254292 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([N:9]2[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]2)[CH:3]=1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>>[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:15](=[O:17])[CH3:16])=[C:4]([N:9]2[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]2)[CH:3]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 577324454-Fluoro-2-(4-methyl-1H-imidazol-1-yl)aniline

Product 1

HCID 57732446N-(4-Fluoro-2-(4-methyl-1H-imidazol-1-yl)phenyl)acetamideYield 64%

Procedure

Reaction of intermediate 2A (17.5 g, 91.4 mmol) and acetic anhydride (90 mL, 914 mmol) provided the product 3A as an off-white powder (13.5 g, 64% yield). EIMS 234.1 [M+H]+.

Sources & evidence

ORD record
ord-49d3eb530c804cd2bbf6799cdfdc0461
Source dataset
uspto-grants-2011_01
Patent number
US07875618B2

Linked notes

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