Glutaric anhydride → Succinimide glutarate

HRID 25473

Reaction equation

HRID 25473 reaction equation
[C:1]([O-:9])(=[O:8])[CH2:2][CH2:3][CH2:4][C:5]([O-:7])=[O:6].C1(=O)OC(=O)CCC1.O[N:19]1[C:23](=[O:24])[CH2:22][CH2:21][C:20]1=[O:25].C1(N=C=NC2CCCCC2)CCCCC1>>[C:1]([OH:9])(=[O:8])[CH2:2][CH2:3][CH2:4][C:5]([OH:7])=[O:6].[C:20]1(=[O:25])[NH:19][C:23](=[O:24])[CH2:22][CH2:21]1

Participants

5

Reactant 4

HCID 7940Glutaric anhydrideHCID 10868DicyclohexylcarbodiimideHCID 80170N-HydroxysuccinimideHCID 4418048Glutarate(2-)

Product 1

HCID 86592295Succinimide glutarate

Procedure

As depicted in above Scheme 2, 6-arm PEG (1) synthesized in the Scheme 1 is reacted with glutarate reagents, e.g., glutaric anhydride to synthesize 6-arm PEG-glutatic acid (6-arm PEG-GA) (2). The compound (2) was reacted with N-hydroxy succinimide (NHS) and N, N′-dicyclohexylcarbodiimide (DCC) to produce 6-arm PEG-succinimide glutarate (6-arm PEG-SG) (3).

Workup

  1. customsynthesized in the Scheme 1

Sources & evidence

ORD record
ord-21362a60159840c9abdcc13b32c63fc9
Source dataset
uspto-grants-2005_02
Patent number
US06858736B2

Linked notes

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