Benzyl Alcohol → Benzyl fluoroformate

HRID 25482

Reaction equation

HRID 25482 reaction equation
[F-:1].[Na+].C(#N)C.[CH2:6]([OH:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(C[O:18][CH3:19])OC>>[F:1][C:19]([O:13][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:18]

Participants

5

Reactant 4

HCID 244Benzyl AlcoholHCID 5235Sodium Fluoride2×HCID 6342AcetonitrileHCID 80711,2-Dimethoxyethane

Product 1

HCID 3023023Benzyl fluoroformate

Procedure

The process is performed as in Example 1 with, in the first reactor, 168 g (4 mol) of sodium fluoride powder having the same characteristics as described in Example 1 and 320 ml of acetonitrile and, in the second reactor, 108 g (1 mol) of benzyl alcohol, 50.5 g (1.2 mol) of sodium fluoride of the same characteristics as above and 150 g of dimethoxyethane.

Sources & evidence

ORD record
ord-868776c4aa2e4da9aec0e9e64cce3e8d
Source dataset
uspto-grants-2005_02
Patent number
US06858751B1

Linked notes

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