Iodoethane → Ethyl 2,6-bis(trifluoromethyl)-4-ethoxy-3-pyridinecarboxylate

Reaction equation

[F:1][C:2]([F:20])([F:19])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7]([OH:14])[CH:6]=[C:5]([C:15]([F:18])([F:17])[F:16])[N:4]=1.[CH2:21](I)[CH3:22]>>[F:20][C:2]([F:19])([F:1])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7]([O:14][CH2:21][CH3:22])[CH:6]=[C:5]([C:15]([F:18])([F:17])[F:16])[N:4]=1

Participants

Reactant 2

HCID 6340Iodoethane

HCID 178470034HCID 178470034, compound

Product 1

HCID 13882869Ethyl 2,6-bis(trifluoromethyl)-4-ethoxy-3-pyridinecarboxylateYield 77%

Procedure

This material was prepared following the procedure of Example 4 in 77% yield from product of Example 2 and ethyl iodide as a white solid; mp 57°-59° C.

Workup

customThis material was prepared

Sources & evidence

ORD record: ord-20454b4d9bc74f1b969cc6d33336347b
Source dataset: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04698093

Reaction notes

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