Trifluoroacetic acid → HCID 178457203, compound

HRID 25599

Reaction equation

HRID 25599 reaction equation
[CH3:1][NH:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]OS(C)(=O)=O)[CH2:5][CH2:4]1.F[C:20](F)(F)C(O)=O.Cl[C:27]([O:29][C:30]1[CH:35]=[CH:34][C:33]([Br:36])=[CH:32][CH:31]=1)=[O:28].[CH2:37]([CH2:40][NH2:41])[CH:38]=C>>[Br:36][C:33]1[CH:34]=[CH:35][C:30]([O:29][C:27](=[O:28])[N:2]([C@H:3]2[CH2:4][CH2:5][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:41]([CH2:40][CH:37]=[CH2:38])[CH3:20])[CH2:7][CH2:8]2)[CH3:1])=[CH:31][CH:32]=1

Participants

5

Reactant 4

HCID 6422Trifluoroacetic acidHCID 4437323-Buten-1-amineHCID 52377364-Bromophenyl chloroformateHCID 178484796HCID 178484796, compound

Product 1

HCID 178457203HCID 178457203, compound

Procedure

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester.trifluoroacetic acid salt and 4-bromophenyl chloroformate were reacted, followed by treatment with N-allylmethylamine to yield trans-{4-[5-(Allyl-methyl-amino)-pentyl]-cyclohexyl}-methyl-carbamic acid 4-bromo-phenyl ester, MS: 451 (MH+, 1Br).

Sources & evidence

ORD record
ord-777aa1cf4ec24098ac52fe58e9c412aa
Source dataset
uspto-grants-2005_02
Patent number
US06858651B2

Linked notes

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