Trifluoroacetic acid → HCID 178464452, compound

HRID 25602

Reaction equation

HRID 25602 reaction equation
[CH3:1][NH:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]OS(C)(=O)=O)[CH2:5][CH2:4]1.FC(F)(F)C(O)=O.Cl[C:27]([O:29][C:30]1[CH:35]=[CH:34][C:33]([F:36])=[C:32]([F:37])[CH:31]=1)=[O:28].[CH2:38]([NH:40][CH2:41][CH2:42][OH:43])[CH3:39]>>[F:37][C:32]1[CH:31]=[C:30]([O:29][C:27](=[O:28])[N:2]([C@H:3]2[CH2:4][CH2:5][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:40]([CH2:38][CH3:39])[CH2:41][CH2:42][OH:43])[CH2:7][CH2:8]2)[CH3:1])[CH:35]=[CH:34][C:33]=1[F:36]

Participants

5

Reactant 4

HCID 6422Trifluoroacetic acidHCID 80722-(Ethylamino)ethanolHCID 225679993,4-Difluorophenyl chloroformateHCID 178484796HCID 178484796, compound

Product 1

HCID 178464452HCID 178464452, compound

Procedure

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester.trifluoroacetic acid salt and 3,4-difluoro-phenyl chloroformate were reacted, followed by treatment with 2-ethylamino-ethanol to yield trans-(4-{5-[Ethyl-(2-hydroxy-ethyl)-amino]-pentyl}-cyclohexyl)-methyl-carbamic acid 3,4-difluoro-phenyl ester, MS: 427 (MH+).

Sources & evidence

ORD record
ord-5b044c6697134f7598e070df0eb3de79
Source dataset
uspto-grants-2005_02
Patent number
US06858651B2

Linked notes

Loading…