Trifluoroacetic acid → HCID 178457209, compound

HRID 25603

Reaction equation

HRID 25603 reaction equation
[CH3:1][NH:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]OS(C)(=O)=O)[CH2:5][CH2:4]1.F[C:20](F)(F)C(O)=O.[F:26][C:27]([F:39])([F:38])[C:28]1[CH:33]=[CH:32][C:31]([S:34](Cl)(=[O:36])=[O:35])=[CH:30][CH:29]=1.[CH2:40]([CH2:43][NH2:44])[CH:41]=C>>[CH2:43]([N:44]([CH3:20])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C@H:6]1[CH2:5][CH2:4][C@H:3]([N:2]([CH3:1])[S:34]([C:31]2[CH:32]=[CH:33][C:28]([C:27]([F:39])([F:38])[F:26])=[CH:29][CH:30]=2)(=[O:36])=[O:35])[CH2:8][CH2:7]1)[CH:40]=[CH2:41]

Participants

5

Reactant 4

HCID 6422Trifluoroacetic acidHCID 4437323-Buten-1-amineHCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 178484796HCID 178484796, compound

Product 1

HCID 178457209HCID 178457209, compound

Procedure

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester.trifluoroacetic acid salt and 4-(trifluoromethyl)benzenesulphonyl chloride were reacted, followed by treatment with N-allylmethylamine to yield trans-N-{4-[5-(Allyl-methyl-amino)-pentyl]-cyclohexyl}-N-methyl-4-trifluoromethyl-benzenesulfonamide, MS: 461 (MH+).

Sources & evidence

ORD record
ord-b16cec55f2074abf9cd51125741926ed
Source dataset
uspto-grants-2005_02
Patent number
US06858651B2

Linked notes

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