Hydrochloric Acid → HCID 13854115, compound

Reaction equation

C([O:3][C:4]([CH:6]([NH:15][CH:16]1[CH2:22][S:21][CH:20]([C:23]2[CH:27]=[CH:26][S:25][CH:24]=2)[CH2:19][N:18]([CH2:28][C:29]([OH:31])=[O:30])[C:17]1=[O:32])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])C.[OH-].[Na+].Cl>>[C:4]([CH:6]([NH:15][CH:16]1[CH2:22][S:21][CH:20]([C:23]2[CH:27]=[CH:26][S:25][CH:24]=2)[CH2:19][N:18]([CH2:28][C:29]([OH:31])=[O:30])[C:17]1=[O:32])[CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)([OH:5])=[O:3]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 14798Sodium Hydroxide

HCID 13854097alpha-[6-(1-Ethoxycarbonyl-3-phenylpropylamino)-5-oxo-2-(3-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid

Product 1

HCID 13854115HCID 13854115, compound

Procedure

150 mg of α-[6-(1-ethoxycarbonyl-3-phenylpropylamino)-5-oxo-2-(3-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid (prepared as described in Example 43) were mixed with 2 ml of a 1N aqueous solution of sodium hydroxide, and the mixture was stirred for 16 hours. The reaction mixture was then adjusted to a pH value of 2.0 with 1N hydrochloric acid and the resulting solid, which was the title compound, was collected by filtration and washed with small amount of water and diisopropyl ether, to yield 120 mg.