Dimethylamine → HCID 178483432, compound

HRID 25609

Reaction equation

HRID 25609 reaction equation
[CH3:1][NH:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]OS(C)(=O)=O)[CH2:5][CH2:4]1.FC(F)(F)C(O)=O.Cl[C:27]([O:29][C:30]1[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=1)=[O:28].[CH3:37][NH:38][CH3:39]>>[Cl:36][C:33]1[CH:34]=[CH:35][C:30]([O:29][C:27](=[O:28])[N:2]([CH3:1])[C@H:3]2[CH2:4][CH2:5][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:38]([CH3:39])[CH3:37])[CH2:7][CH2:8]2)=[CH:31][CH:32]=1

Participants

5

Reactant 4

HCID 674DimethylamineHCID 6422Trifluoroacetic acidHCID 1390594-Chlorophenyl chloroformateHCID 178484796HCID 178484796, compound

Product 1

HCID 178483432HCID 178483432, compound

Procedure

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester.trifluoroacetic acid salt and 4-chlorophenyl chloroformate were reacted, followed by treatment with dimethylamine to give trans-Methyl-{4-[5-(dimethylamino)-pentyl]-cyclohexyl}-carbamic acid 4-chloro-phenyl ester, MS: 381 (MH+, 1Cl).

Sources & evidence

ORD record
ord-5acac1ec5d50455099d11d6c0d1e22b3
Source dataset
uspto-grants-2005_02
Patent number
US06858651B2

Linked notes

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