Bromomethylcyclopropane → HCID 178420903, compound
Reaction equation
[SH:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.C[O-].[Na+].[CH:10]1([CH2:13]Br)[CH2:12][CH2:11]1>CO>[CH:10]1([CH2:13][S:1][C:2]2[N:6]=[CH:5][NH:4][N:3]=2)[CH2:12][CH2:11]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 3-mercapto-1,2,4-triazole (7.1 g) and sodium methoxide (3.8 g) in methanol (100 ml), there was added cyclopropylmethyl bromide (9.5 g), and the resultant mixture was allowed to stand at room temperature for 10 hours. After removal of the solvent, the residue was extracted with chloroform. Evaporation of the chloroform extract gave 10.8 g of 3-cyclopropylmethylthio-1,2,4-triazole. Yield, 99%. M.P., 69°-70° C.
Workup
- customAfter removal of the solvent
- extractionthe residue was extracted with chloroform
- customEvaporation of the chloroform
- extractionextract
Sources & evidence
- ORD record
- ord-5ff60d7a4e704f758b67bc2c184e22e6
- Source dataset
- uspto-grants-1987_10
- Patent number
- US04702764
Reaction notes
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