Hydroxyamine hydrochloride → alpha-Oximino-3-pyridylacetamidoxime
Reaction equation
[N:1](=[C:3]([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)[C:4]#[N:5])[OH:2].Cl.[NH2:13][OH:14].C([O-])(=O)C.[Na+]>C(O)C>[N:1](=[C:3]([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)[C:4](=[N:13][OH:14])[NH2:5])[OH:2]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of alpha-oximino-3-pyridylacetonitrile (41.0 g, 279 mmol), hydroxylamine hydrochloride (21.5 g, 310 mmol) and sodium acetate (50.8 g, 620 mmol) in ethanol (99.9%, 500 ml) was refluxed for 4 h. After cooling, the precipitate was collected by filtration and dried. The precipitate contained the wanted product and sodium acetate (85 g, 168%); M+ : 180.
Workup
- temperaturewas refluxed for 4 h
- temperatureAfter cooling
- filtrationthe precipitate was collected by filtration
- customdried
Sources & evidence
- ORD record
- ord-e550ddabc82f40f189b2f35578a7c2f9
- Source dataset
- uspto-grants-1993_11
- Patent number
- US05260311
Reaction notes
Loading…