N-Methylbenzylamine → 4-(N-benzyl-N-methylamino)-1-(4-nitrophenyl)piperidine fumarate

HRID 257085

Reaction equation

HRID 257085 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH2:17]([NH:24][CH3:25])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30]>>[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30].[CH2:17]([N:24]([CH:13]1[CH2:14][CH2:15][N:10]([C:7]2[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[CH2:11][CH2:12]1)[CH3:25])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 3

HCID 7669N-MethylbenzylamineHCID 444972Fumaric AcidHCID 38425621-(4-Nitrophenyl)piperidin-4-one

Product 1

HCID 197843954-(N-benzyl-N-methylamino)-1-(4-nitrophenyl)piperidine fumarate

Procedure

1-(4-Nitrophenyl)-4-piperidone was reacted in a similar manner to Example 2 with N-benzyl-N-methylamine and then with fumaric acid. 4-(N-benzyl-N-methylamino)-1-(4-nitrophenyl)piperidine fumarate was obtained. Melting point 183° C.

Sources & evidence

ORD record
ord-6f862ca5557847b495ce182f15eba9fb
Source dataset
uspto-grants-1993_11
Patent number
US05260318

Linked notes

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