Methylamine → N-methyl-5-nitropyridin-2-amine
Reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][C:7](Cl)=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH3:11][NH2:12]>C(O)C>[N+:1]([C:4]1[CH:5]=[N:6][C:7]([NH:12][CH3:11])=[CH:8][CH:9]=1)([O-:3])=[O:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3-Nitro-6-chloropyridine (5 g, 31.5 mmol) was added to 10 ml of a 30% solution of methylamine in ethanol, followed by reaction at room temperature for 5 minutes. Then, recrystallization from chloroform-hexane gave 4.92 g of the intended product as yellow crude crystals.
Workup
- customfollowed by reaction at room temperature for 5 minutes
- customThen, recrystallization from chloroform-hexane
Sources & evidence
- ORD record
- ord-44b7ea052e4c4c96a317178936f110bd
- Source dataset
- uspto-grants-1993_11
- Patent number
- US05262415
Reaction notes
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