Iodoethane → 1-Phenyl-3-(3-n-propyl-4-pyridyl)butane

HRID 257474

Reaction equation

[C:1]1([CH2:7][CH2:8][CH:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[CH3:17])[CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:18](I)[CH3:19].[Li].C(NC(C)C)(C)C>>[C:1]1([CH2:7][CH2:8][CH:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[CH2:17][CH2:18][CH3:19])[CH3:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Reactant 3

HCID 6340Iodoethane

HCID 197832971-Phenyl-3-(3-methyl-4-pyridyl)butane

HCID 45051747Lithium diisopropylamine

Product 1

HCID 197833201-Phenyl-3-(3-n-propyl-4-pyridyl)butaneYield 15.6%

Procedure

2.1 g (9.35 mmol) of 1-phenyl-3-(3-methyl-4-pyridyl)butane, 1.46 g (9.35 mmol) of ethyl iodide and 2 equivalent of lithium-diisopropylamine were reacted in the same manner as in Example 1. The reaction product was purified to obtain 0.37 g of the desired compound (yield: 15.6%).

Workup

customThe reaction product was purified

Sources & evidence

ORD record: ord-050c0500979a4433a4718a4be18e859c
Source dataset: uspto-grants-1993_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05262420

Linked notes

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