Potassium Hydroxide → 4-Benzenesulphonamido-1-(4-phenylbutyl)piperidine
Reaction equation
[C:1]1([S:7]([NH:10][CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=O)[CH2:13][CH2:12]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.NN.[OH-].[K+]>>[C:1]1([S:7]([NH:10][CH:11]2[CH2:12][CH2:13][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:15][CH2:16]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1Participants
4
Procedure
4-Benzenesulphonamido-1-(4-phenyl-4-oxobutyl)piperidine may be reacted with hydrazine hydrate and potassium hydroxide under Wolff-Kishner reaction conditions to give the title compound.
Sources & evidence
- ORD record
- ord-a217e79036eb4b8ca16a94696223fd34