Hydrazine Sulfate → HCID 178433316, compound

HRID 258744

Reaction equation

HRID 258744 reaction equation
[ClH:1].Cl.Cl.O[N:5]([CH2:19][CH2:20][S:21][CH2:22][C:23]1[NH:27][CH:26]=[N:25][C:24]=1[CH3:28])[C:6]([NH2:18])=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[NH:16][CH:15]=[N:14][C:13]=1[CH3:17].S(O)(O)(=O)=O.[NH2:34]N.C(=O)([O-])O.[K+]>CN(C)C=O>[ClH:1].[ClH:1].[ClH:1].[NH2:34][NH:18][C:6]([NH:5][CH2:19][CH2:20][S:21][CH2:22][C:23]1[NH:27][CH:26]=[N:25][C:24]=1[CH3:28])=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[NH:16][CH:15]=[N:14][C:13]=1[CH3:17]

Participants

5

Reactant 3

HCID 24842Hydrazine SulfateHCID 516893Potassium BicarbonateHCID 178433318HCID 178433318, compound

Product 1

HCID 178433316HCID 178433316, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of the isothiourea trihydrochloride from Example 2 (ii) (5.1 g), hydrazine sulphate (1.6 g), potassium hydrogen carbonate (7.0 g) and anhydrous dimethyl formamide (60 ml) was stirred at 70° for 3 hours. Following cooling and filtration the filtrate containing the free base was treated with an excess of ethanolic hydrogen chloride to give the title compound.

Workup

  1. temperatureFollowing cooling
  2. filtrationfiltration the filtrate
  3. additioncontaining the free base
  4. additionwas treated with an excess of ethanolic hydrogen chloride

Sources & evidence

ORD record
ord-bded5c2ab36842c086cd8244c474c63f
Source dataset
uspto-grants-1977_07
Patent number
US04034101

Linked notes

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