Chlorine → Maltol

HRID 25906

Reaction equation

HRID 25906 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]([OH:8])[CH3:7].Cl[O-:10].[Na+].ClCl>O1CCCC1.O>[CH3:7][C:6]1[O:8][CH:5]=[CH:4][C:3](=[O:10])[C:2]=1[OH:1]

Participants

6

Reactant 3

HCID 24526ChlorineHCID 1072431-(2-Furyl)ethanolHCID 23665760Sodium Hypochlorite

Product 1

HCID 8369Maltol

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 1(2-furyl)-1-ethanol (0.05 mole) in 15 ml of tetrahydrofuran and 15 ml of water at 5° C. is added 21.7 ml of 2.8 M sodium hypochlorite solution. Chlorine (0.05 mole) is added to the reaction flask via a gas inlet tube maintaining the reaction temperature below 5° C. The reaction mixture is then heated to reflux and the tetrahydrofuran removed by distillation. Heating is continued for an additional hour. The reaction mixture is cooled and maltol is isolated by the procedure described in Example 1.

Workup

  1. temperaturemaintaining the reaction temperature below 5° C
  2. temperatureThe reaction mixture is then heated
  3. temperatureto reflux
  4. customthe tetrahydrofuran removed by distillation
  5. temperatureHeating
  6. waitis continued for an additional hour
  7. temperatureThe reaction mixture is cooled

Sources & evidence

ORD record
ord-09e8b01cef48419b8f8d5e7670f29be6
Source dataset
uspto-grants-1979_04
Patent number
US04147705

Linked notes

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