Hydrochloric Acid → HCID 20356988, compound
Reaction equation
[CH2:1]1[O:13][C:12]2[CH:11]=[C:10]3[C:5]([C:6](=[O:24])[C:7]([C:19]([O:21]CC)=[O:20])=[CH:8][N:9]3[CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:4][C:3]=2[O:2]1.Cl>>[CH2:1]1[O:13][C:12]2[CH:11]=[C:10]3[C:5]([C:6](=[O:24])[C:7]([C:19]([OH:21])=[O:20])=[CH:8][N:9]3[CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:4][C:3]=2[O:2]1Participants
3
Procedure
A mixture of 1 g. of the ethyl ester obtained from Example 3 and 40 ml. of 6N. hydrochloric acid was heated under reflux for 11/2 hours. The mixture was cooled and the solid product was collected by filtration and washed with water and dried under reduced pressure, m.p. 323°-5° C. (dec.).
Workup
- additionA mixture of 1 g
- temperatureunder reflux for 11/2 hours
- temperatureThe mixture was cooled
- filtrationthe solid product was collected by filtration
- washwashed with water
- customdried under reduced pressure, m.p. 323°-5° C. (dec.)