Dibutylcarbamoyl chloride → 1,1-Dibutyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

HRID 259334

Reaction equation

[CH2:1]([N:5]([CH2:9][CH2:10][CH2:11][CH3:12])[C:6](Cl)=[O:7])[CH2:2][CH2:3][CH3:4].[S:13]1[CH:17]=[CH:16][C:15]2[CH:18]([NH2:22])[CH2:19][CH2:20][CH2:21][C:14]1=2>>[CH2:1]([N:5]([CH2:9][CH2:10][CH2:11][CH3:12])[C:6]([NH:22][CH:18]1[C:15]2[CH:16]=[CH:17][S:13][C:14]=2[CH2:21][CH2:20][CH2:19]1)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 83371Dibutylcarbamoyl chloride

HCID 42163724,5,6,7-Tetrahydro-1-benzothiophen-4-amine

Product 1

HCID 203489471,1-Dibutyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

Procedure

Similarly, diethyl-, dipropyl-, and dibutylcarbamoyl chloride are reacted with 4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine to afford 1,1-diethyl-, 1,1-dipropyl-, and 1,1-dibutyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea, respectively. Substitution of the above-mentioned carbamoyl chlorides with the corresponding thiocarbamoyl chlorides affords the corresponding thioureas.

Sources & evidence

ORD record: ord-9a432fcd75d641c58cc0b0316a280d0e
Source dataset: uspto-grants-1977_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04036979

Linked notes

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