Hydrochloric Acid → HCID 21422240, compound

HRID 259531

Reaction equation

HRID 259531 reaction equation
[Cl:1][S:2]([OH:5])(=[O:4])=[O:3].[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH3:16])[CH:11]=[CH:12][C:13]=1[O:14][CH3:15].Cl>C1C=CC=CC=1>[S:2]([Cl:1])([OH:5])(=[O:4])=[O:3].[CH3:16][C:10]1[CH:9]=[C:8]([O:7][CH3:6])[C:13]([O:14][CH3:15])=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24638Chlorosulfonic acidHCID 681263,4-Dimethoxytoluene

Product 1

HCID 21422240HCID 21422240, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

23.2 gm (0.2 mol) of chlorosulfonic acid were slowly added dropwise to 15.2 gm (0.1 mol) of 3,4-dimethoxy-toluene at about - 10° C., while stirring and cooling. Afterwards, the mixture was allowed to warm to room temperature, and was then stirred until the evolution of hydrogen chloride ceased. The reaction mixture was poured over ice, and the precipitated sulfochloride was extracted with ether. The organic phase was successively washed with sodium bicarbonate solution and water, and then evaporated to dryness in vacuo. A turbid oil was obtained as a residue, which solidified after cooling. Rf -value (benzene): 0.5.

Workup

  1. temperaturecooling
  2. additionThe reaction mixture was poured over ice
  3. extractionthe precipitated sulfochloride was extracted with ether
  4. washThe organic phase was successively washed with sodium bicarbonate solution and water
  5. customevaporated to dryness in vacuo
  6. customA turbid oil was obtained as a residue
  7. temperatureafter cooling

Sources & evidence

ORD record
ord-8da7098edd54451688031f7be482a051
Source dataset
uspto-grants-1977_07
Patent number
US04038407

Linked notes

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