Phosphinic Acid → 1-Benzhydrylamino-2-methylpropanephosphonous acid

HRID 25973

Reaction equation

HRID 25973 reaction equation
[PH2:1]([OH:3])=[O:2].[CH:4](=[N:8][CH:9]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH:5]([CH3:7])[CH3:6]>C(O)C>[CH:9]([NH:8][CH:4]([P:1]([OH:3])[OH:2])[CH:5]([CH3:7])[CH3:6])([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 4124402Phosphinic AcidHCID 10657527Isobutylidenebenzhydrylamine

Product 1

HCID 213258821-Benzhydrylamino-2-methylpropanephosphonous acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Hypophosphorous acid (100%, 15.8 parts) dissolved in absolute ethanol was added to a stirred solution of 41.3 parts isobutylidenebenzhydrylamine in absolute ethanol. An exothermic reaction occurred. After standing one hour the reaction was filtered and the white solid dried in vacuo. There was obtained DL-1-benzhydrylamino-2-methylpropanephosphonous acid, melting point 191° (dec.).

Workup

  1. customAn exothermic reaction
  2. filtrationthe reaction was filtered
  3. customthe white solid dried in vacuo

Sources & evidence

ORD record
ord-bee6e3df24624b6d98464e0a489e9362
Source dataset
uspto-grants-1979_04
Patent number
US04147780

Linked notes

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