Valproic Acid → 2-Propylvaleryl chloride

HRID 260201

Reaction equation

HRID 260201 reaction equation
[C:1]([OH:10])(=O)[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].S(Cl)([Cl:13])=O>C1C=CC=CC=1>[C:1]([Cl:13])(=[O:10])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 3121Valproic AcidHCID 24386Thionyl Chloride

Product 1

HCID 762402-Propylvaleryl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
50 °C

Procedure

To 4.32 g (30 mmol) of valproic acid in an ice bath, thionyl chloride (3.60 g, 30 mmol) was slowly added, with stirring. The neat mixture was allowed to come to room temperature and then heated in a water bath at 50° C. for 30 minutes. 50 M1 portions of dry benzene were twice added and removed under reduced pressure. The resultant product was used in subsequent reactions without further purification.

Workup

  1. customto come to room temperature
  2. customremoved under reduced pressure
  3. customThe resultant product was used in subsequent reactions without further purification

Sources & evidence

ORD record
ord-7062ea72074043e7bf4ec57d183adc6d
Source dataset
uspto-grants-1996_06
Patent number
US05525727

Linked notes

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