Valproic Acid → 2-Propylvaleryl chloride
Reaction equation
[C:1]([OH:10])(=O)[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].S(Cl)([Cl:13])=O>C1C=CC=CC=1>[C:1]([Cl:13])(=[O:10])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
To 4.32 g (30 mmol) of valproic acid in an ice bath, thionyl chloride (3.60 g, 30 mmol) was slowly added, with stirring. The neat mixture was allowed to come to room temperature and then heated in a water bath at 50° C. for 30 minutes. 50 M1 portions of dry benzene were twice added and removed under reduced pressure. The resultant product was used in subsequent reactions without further purification.
Workup
- customto come to room temperature
- customremoved under reduced pressure
- customThe resultant product was used in subsequent reactions without further purification
Sources & evidence
- ORD record
- ord-7062ea72074043e7bf4ec57d183adc6d
- Source dataset
- uspto-grants-1996_06
- Patent number
- US05525727
Reaction notes
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