Pyridine → 2-Pyrrolidinone, 3-hydroxy-1-methyl-5-(3-pyridinyl)-

HRID 260251Notes

Reaction equation

HRID 260251 reaction equation
N1C=CC=CC=1.[CH3:7][N:8]1[C:12](=[O:13])[C@H:11]([OH:14])[CH2:10][C@H:9]1[C:15]1[CH:20]=[CH:19][CH:18]=[N:17][CH:16]=1>CN(C=O)C.C1(=O)OC(=O)CC1>[CH3:7][N:8]1[C:12](=[O:13])[CH:11]([OH:14])[CH2:10][CH:9]1[C:15]1[CH:20]=[CH:19][CH:18]=[N:17][CH:16]=1

Participants

5

Reactant 2

HCID 1049PyridineHCID 1079633'-Hydroxycotinine, trans-

Product 1

HCID 4142-Pyrrolidinone, 3-hydroxy-1-methyl-5-(3-pyridinyl)-

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 7922Succinic anhydrideSolvent

Procedure

Hydroxycotinine hemisuccinate was prepared as follows. In a glass tube, 19 mg of trans-3'-hydroxycotinine were dissolved in 1 ml of DMF. In this solution 21 mg of succinic anhydride were dissolved. After adding 20 μl of pyridine, the tube was covered (PARAFILM®) and incubated overnight at 37° C.

Workup

  1. custom(PARAFILM®) and incubated overnight
  2. customat 37° C.

Sources & evidence

ORD record
ord-75f5640dafa64d76af267b510fdfec74
Source dataset
uspto-grants-1996_06
Patent number
US05527686

Reaction notes

Loading…