1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 2-Pyrrolidinone, 3-hydroxy-1-methyl-5-(3-pyridinyl)-

HRID 260254

Reaction equation

[CH3:1][N:2]1[C:6](=[O:7])[CH2:5][CH2:4][C@H:3]1[C:8]1[CH:9]=[CH:10][CH:11]=[N:12][CH:13]=1.[OH:14]N1C(=O)CCC1=O.C(N=C=NCCCN(C)C)C>>[CH3:1][N:2]1[C:6](=[O:7])[CH:5]([OH:14])[CH2:4][CH:3]1[C:8]1[CH:9]=[CH:10][CH:11]=[N:12][CH:13]=1

Participants

Reactant 3

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide

HCID 80170N-Hydroxysuccinimide

HCID 854019Cotinine

Product 1

HCID 4142-Pyrrolidinone, 3-hydroxy-1-methyl-5-(3-pyridinyl)-

Procedure

Hydroxycotinine hemisuccinate succinic ester was prepared by adding to 1 ml of cotinine hemisuccinate 14 mg of N-hydroxysuccinimide (Sigma) and 23 mg of 1-ethyl-3-(dimethylaminopropyl) carbodiimide (Sigma) and incubating at room temperature for 3 ]]ours.

Workup

customincubating at room temperature for 3 ]]ours

Sources & evidence

ORD record: ord-fa2142ef38c543bea86ec988990e1d14
Source dataset: uspto-grants-1996_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05527686

Linked notes

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