Glutaric anhydride → HCID 22861973, compound
Reaction equation
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[CH3:9][O:10][C:11](=[O:46])[C@H:12]([CH2:27][C:28]1[CH:35]=[C:33]([I:34])[C:32]([O:36][C:37]2[CH:44]=[C:42]([I:43])[C:41]([OH:45])=[C:39]([I:40])[CH:38]=2)=[C:30]([I:31])[CH:29]=1)[NH:13][C:14](=[O:26])[CH2:15][CH2:16][CH2:17][C:18]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)=[O:19]>>[CH3:9][O:10][C:11](=[O:46])[C@H:12]([CH2:27][C:28]1[CH:35]=[C:33]([I:34])[C:32]([O:36][C:37]2[CH:44]=[C:42]([I:43])[C:41]([OH:45])=[C:39]([I:40])[CH:38]=2)=[C:30]([I:31])[CH:29]=1)[NH:13][C:14](=[O:26])[CH2:15][CH2:16][CH2:17][C:18]([N:20]1[CH2:25][CH2:24][N:23]([C:5](=[O:6])[CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8])[CH2:22][CH2:21]1)=[O:19]Participants
3
Procedure
This material was prepared using the procedure outlined in Intermediate Preparation 1, step 6 except glutaric anhydride was reacted with N-(4-piperazinocarbonylbutyryl)thyroxine methyl ester hydromide from step 4. This compound was purified by column chromatography (SiO2).
Workup
- customThis material was prepared
- customThis compound was purified by column chromatography (SiO2)
Sources & evidence
- ORD record
- ord-33853c55ea364fde9b24dff330aaddda