Phosphorus oxychloride → HCID 22401591, compound

Reaction equation

[CH2:1]([C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]=1[NH2:13])[CH3:2].C([N:17]1[CH2:21][CH2:20][NH:19][C:18]1=O)(=O)C.O=P(Cl)(Cl)Cl>>[CH2:1]([C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]=1[NH:13][C:18]1[NH:19][CH2:20][CH2:21][N:17]=1)[CH3:2]

Participants

Reactant 3

HCID 24813Phosphorus oxychloride

HCID 79350N-Acetylimidazolidinone

HCID 422871HCID 422871, compound

Product 1

HCID 22401591HCID 22401591, compound

Procedure

2-Ethylnaphthyl amine is reacted with N-acetyl-2imidazolidinone in the presence of POCl3 to produce the imidazoline intermediate. This intermediate is treated with sodium hydroxide and water to remove the aceto group and yield the name compound (VIII).

Sources & evidence

ORD record: ord-e02f8465e06a47d0b19e7413c530f73b
Source dataset: uspto-grants-1996_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05527830

Reaction notes

Loading…