2-Amino-5-methylthiazole → HCID 22401741, compound

HRID 260528

Reaction equation

HRID 260528 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)=[O:4].[CH3:10][C:11]1[S:15][C:14]([NH2:16])=[N:13][CH:12]=1>C(#N)C>[BrH:1].[NH:16]=[C:14]1[N:13]([CH2:2][C:3]([C:5]2[S:6][CH:7]=[CH:8][CH:9]=2)=[O:4])[CH:12]=[C:11]([CH3:10])[S:15]1

Participants

4

Reactant 2

HCID 3517702-Amino-5-methylthiazoleHCID 27763722-Bromo-1-(thiophen-2-yl)ethan-1-one

Product 1

HCID 22401741HCID 22401741, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 51 parts of 2-bromo-1-(2-thienyl)ethanone, 28.5 parts of 5-methyl-2-thiazolamine and 240 parts of acetonitrile was stirred for 1 hour while heating on a water-bath. After cooling, the precipitate was filtered off, washed with ethanol and dried in vacuo, yielding 54 parts of 2-(2,3-dihydro-2-imino-5-methyl-3-thiazolyl)-1-(2-thienyl)ethanone hydrobromide; mp. 207.5°-208° C (interm. 56).

Workup

  1. temperaturewhile heating on a water-bath
  2. temperatureAfter cooling
  3. filtrationthe precipitate was filtered off
  4. washwashed with ethanol
  5. customdried in vacuo

Sources & evidence

ORD record
ord-f21da8212cc340c0b8a25b691cce9bce
Source dataset
uspto-grants-1996_06
Patent number
US05527915

Linked notes

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